What Are Ghost Peaks and How Are They Related to Solvent Impurities?
Direct Answer
A Ghost Peak is an unexpected chromatographic peak that cannot be linked to the intended sample components.
In HPLC, Ghost Peaks may come from:
Impurities in the mobile phase or solvents
Contamination from the HPLC system
Carryover from a previous injection
Contaminated sample preparation materials
Column contamination or strongly retained compounds
Additives, buffers, or water used to prepare the mobile phase
Contamination from containers, tubing, filters, or other consumables
Therefore, solvent impurities are one possible source of Ghost Peaks, but they are not the only cause.